Implications of enolase in the RANKL-mediated osteoclast activity following spinal cord injury

Spinal Cord Injury (SCI) is a debilitating condition characterized by damage to the spinal cord, resulting in loss of function, mobility, and sensation. Although increasingly prevalent US, no FDA-approved therapy exists due unfortunate complexity condition, difficulties SCI may be furthered development SCI-related complications, such as osteoporosis. demonstrates two crucial stages for consideration: primary stage secondary stage. While suggested immediate irreversible, proposed promising window opportunity therapeutic intervention. Enolase, metabolic enzyme upregulated after SCI, performs non-glycolytic functions, promoting inflammatory events via extracellular degradative actions increased production cytokines chemokines. Neuron-specific enolase (NSE) serves biomarker functional neurons following inhibition NSE has been demonstrated reduce signs injury ameliorate dysfunction. This Viewpoint article involves activation regulation RANK-RANKL pathway summarizes succinctly mechanisms influencing osteoclast-mediated resorption bone SCI. Our laboratory proposes that SCI-induced response decrease osteoclast activity, limiting chances skeletal tissue